Barts Health Knowledge and Library Services’ Assad Lahlou goes through Question 1 of the CASP RCT Checklist, “Did the study address a clear focus question?” in relation to the following paper: Uchio Y, Enomoto H, Alev L, Kato Y, Ishihara H, Tsuji T, Ochiai T, Konno S. A randomized, double-blind, placebo-controlled Phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis. J Pain Res. 2018 Apr 18;11:809-821. doi: 10.2147/JPR.S164128. PMID: 29713194; PMCID: PMC5912377. Download the CASP RCT Checklist: https://casp-uk.b-cdn.net/wp-content/uploads/2020/10/CASP_RCT_Checklist_PDF_Fillable_Form.pdf Visit Barts Knowledge and Library Services: https://bartshealth-nhs.libguides.com/home If you have any question about this training, need further assistance with critical appraisal, would like more video tutorials on how to critically appraise a different type of study or on other topics, please email bartshealth.library@nhs.net

Barts Health Knowledge and Library Services’ Adam Tocock goes through Question 2 of the CASP RCT Checklist, “Was the assignment of participants to interventions randomised?” in relation to the following paper: Uchio Y, Enomoto H, Alev L, Kato Y, Ishihara H, Tsuji T, Ochiai T, Konno S. A randomized, double-blind, placebo-controlled Phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis. J Pain Res. 2018 Apr 18;11:809-821. doi: 10.2147/JPR.S164128. PMID: 29713194; PMCID: PMC5912377. This video features an image from https://www.sealedenvelope.com/help/redpill/latest/block/ and a link to https://www.rdatagen.net/post/permuted-block-randomization-using-simstudy/ Download the CASP RCT Checklist: https://casp-uk.b-cdn.net/wp-content/uploads/2020/10/CASP_RCT_Checklist_PDF_Fillable_Form.pdf Visit Barts Knowledge and Library Services: https://bartshealth-nhs.libguides.com/home

Barts Health Knowledge and Library Services’ Assad Lahlou goes through Question 3 of the CASP RCT Checklist, “Were all participants who entered the study accounted for at its conclusion?” in relation to the following paper: Uchio Y, Enomoto H, Alev L, Kato Y, Ishihara H, Tsuji T, Ochiai T, Konno S. A randomized, double-blind, placebo-controlled Phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis. J Pain Res. 2018 Apr 18;11:809-821. doi: 10.2147/JPR.S164128. PMID: 29713194; PMCID: PMC5912377. Download the CASP RCT Checklist: https://casp-uk.b-cdn.net/wp-content/uploads/2020/10/CASP_RCT_Checklist_PDF_Fillable_Form.pdf Visit Barts Knowledge and Library Services: https://bartshealth-nhs.libguides.com/home If you have any question about this training, need further assistance with critical appraisal, would like more video tutorials on how to critically appraise a different type of study or on other topics, please email bartshealth.library@nhs.net

Barts Health Knowledge and Library Services’ Assad Lahlou goes through Question 4 of the CASP RCT Checklist, “Were patients, health workers and study personnel blinded?” in relation to the following paper: Uchio Y, Enomoto H, Alev L, Kato Y, Ishihara H, Tsuji T, Ochiai T, Konno S. A randomized, double-blind, placebo-controlled Phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis. J Pain Res. 2018 Apr 18;11:809-821. doi: 10.2147/JPR.S164128. PMID: 29713194; PMCID: PMC5912377. This video features modified images from Barts Health NHS Trust. Download the CASP RCT Checklist: https://casp-uk.b-cdn.net/wp-content/uploads/2020/10/CASP_RCT_Checklist_PDF_Fillable_Form.pdf Visit Barts Knowledge and Library Services: https://bartshealth-nhs.libguides.com/home If you have any question about this training, need further assistance with critical appraisal, would like more video tutorials on how to critically appraise a different type of study or on other topics, please email: mailto:bartshealth.library@nhs.net

Barts Health Knowledge and Library Services’ Adam Tocock goes through Question 5 of the CASP checklist, “Were the study groups similar at the start of the randomised controlled trial?” in relation to the following paper: Uchio Y, Enomoto H, Alev L, Kato Y, Ishihara H, Tsuji T, Ochiai T, Konno S. A randomized, double-blind, placebo-controlled Phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis. J Pain Res. 2018 Apr 18;11:809-821. doi: 10.2147/JPR.S164128. PMID: 29713194; PMCID: PMC5912377. Download the CASP RCT Checklist: https://casp-uk.b-cdn.net/wp-content/uploads/2020/10/CASP_RCT_Checklist_PDF_Fillable_Form.pdf Visit Barts Knowledge and Library Services: https://bartshealth-nhs.libguides.com/home

Barts Health Knowledge and Library Services’ Assad Lahlou goes through Question 6 of the CASP RCT Checklist,“Apart from the experimental intervention, did each study group receive the same level of care (that is, were they treated equally)?” in relation to the following paper: Uchio Y, Enomoto H, Alev L, Kato Y, Ishihara H, Tsuji T, Ochiai T, Konno S. A randomized, double-blind, placebo-controlled Phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis. J Pain Res. 2018 Apr 18;11:809-821. doi: 10.2147/JPR.S164128. PMID: 29713194; PMCID: PMC5912377. Download the CASP RCT Checklist: https://casp-uk.b-cdn.net/wp-content/uploads/2020/10/CASP_RCT_Checklist_PDF_Fillable_Form.pdf Visit Barts Knowledge and Library Services: https://bartshealth-nhs.libguides.com/home If you have any question about this training, need further assistance with critical appraisal, would like more video tutorials on how to critically appraise a different type of study or on other topics, please email bartshealth.library@nhs.net

Barts Health Knowledge and Library Services’ Adam Tocock goes through Question 7 of the CASP checklist: “Were the effects of intervention reported comprehensively?” in relation to the following paper: Uchio Y, Enomoto H, Alev L, Kato Y, Ishihara H, Tsuji T, Ochiai T, Konno S. A randomized, double-blind, placebo-controlled Phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis. J Pain Res. 2018 Apr 18;11:809-821. doi: 10.2147/JPR.S164128. PMID: 29713194; PMCID: PMC5912377. This video features an image from https://xkcd.com/1478/ Download the CASP RCT Checklist: https://casp-uk.b-cdn.net/wp-content/uploads/2020/10/CASP_RCT_Checklist_PDF_Fillable_Form.pdf Visit Barts Knowledge and Library Services: https://bartshealth-nhs.libguides.com/home

Barts Health Knowledge and Library Services’ Assad Lahlou goes through Question 8 of the CASP RCT Checklist,“Was the precision of the estimate of the intervention or treatment effect reported?” in relation to the following paper: Uchio Y, Enomoto H, Alev L, Kato Y, Ishihara H, Tsuji T, Ochiai T, Konno S. A randomized, double-blind, placebo-controlled Phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis. J Pain Res. 2018 Apr 18;11:809-821. doi: 10.2147/JPR.S164128. PMID: 29713194; PMCID: PMC5912377. Download the CASP RCT Checklist: https://casp-uk.b-cdn.net/wp-content/uploads/2020/10/CASP_RCT_Checklist_PDF_Fillable_Form.pdf Visit Barts Knowledge and Library Services: https://bartshealth-nhs.libguides.com/home If you have any question about this training, need further assistance with critical appraisal, would like more video tutorials on how to critically appraise a different type of study or on other topics, please email bartshealth.library@nhs.net

Barts Health Knowledge and Library Services’ Assad Lahlou goes through Question 9 of the CASP RCT Checklist,“Do the benefits of the experimental intervention outweigh the harms and costs?” in relation to the following paper: Uchio Y, Enomoto H, Alev L, Kato Y, Ishihara H, Tsuji T, Ochiai T, Konno S. A randomized, double-blind, placebo-controlled Phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis. J Pain Res. 2018 Apr 18;11:809-821. doi: 10.2147/JPR.S164128. PMID: 29713194; PMCID: PMC5912377. Download the CASP RCT Checklist: https://casp-uk.b-cdn.net/wp-content/uploads/2020/10/CASP_RCT_Checklist_PDF_Fillable_Form.pdf Visit Barts Knowledge and Library Services: https://bartshealth-nhs.libguides.com/home If you have any question about this training, need further assistance with critical appraisal, would like more video tutorials on how to critically appraise a different type of study or on other topics, please email bartshealth.library@nhs.net

Barts Health Knowledge and Library Services’ Assad Lahlou goes through Questions 10 and 11 of the CASP RCT Checklist, “Can the results be applied to your local population/ in your context?” and “Would the experimental intervention provide greater value to the people in your care than any of the existing interventions?” in relation to the following paper: Uchio Y, Enomoto H, Alev L, Kato Y, Ishihara H, Tsuji T, Ochiai T, Konno S. A randomized, double-blind, placebo-controlled Phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis. J Pain Res. 2018 Apr 18;11:809-821. doi: 10.2147/JPR.S164128. PMID: 29713194; PMCID: PMC5912377. Download the CASP RCT Checklist: https://casp-uk.b-cdn.net/wp-content/uploads/2020/10/CASP_RCT_Checklist_PDF_Fillable_Form.pdf Visit Barts Knowledge and Library Services: https://bartshealth-nhs.libguides.com/home If you have any question about this training, need further assistance with critical appraisal, would like more video tutorials on how to critically appraise a different type of study or on other topics, please email bartshealth.library@nhs.net